Memory T Lymphocytes in Cancer Immunology (R01)

-Purpose. This Funding Opportunity Announcement (FOA) issued by the National Cancer Institute (NCI), National Institutes of Health (NIH), solicits applications from organizations that propose to conduct basic research studies that are relevant to antitumor immunity and that are focused on memory T lymphocytes and/or the cells and molecules that interact with memory T lymphocytes. Such research may include investigations of T memory cell differentiation, maintenance, and reactivation. Investigations may entail both human and animal studies, and both in vitro and in vivo analyses. Innovative uses of existing technologies and reagents, as well as the development of new technologies and reagents, are encouraged. We anticipate that the results of such research will ultimately improve the prospects for successful cancer immunotherapies and cancer vaccine development. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism and runs in parallel with an FOA of identical scientific scope, PA-06-349, that solicits applications under the Exploratory/Developmental Grant (R21) award mechanism. -Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.